Ingredient · heart

Omega-3 (EPA+DHA)

Heart, brain, and joint support.

Evidence · Strong27 RCTs9 meta-analysises

The evidence

For
heart
Strong
Impact of omega-3 supplementation on lipoprotein-associated phospholipase A2 mass and activity: A systematic review and meta-analysis of randomized controlled trials.
Journal of clinical lipidology · 2026
Omega-3 fatty acids and cardiovascular risk-related metabolic markers in diverse populations: a meta-analysis of randomized trials.
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026
The effectiveness of intervention with omega-3 fatty acids, eicosapentaenoic and docosahexenoic acid in peripheral arterial disease: a systematic review and meta-analysis.
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026
For
joint
Promising
Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials.
Nutrients · 2017
Diet modification reduces pain and improves function in adults with osteoarthritis: a systematic review.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2024
Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial.
The American journal of clinical nutrition · 2022
For
mood
Promising
Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.
Journal of affective disorders · 2025
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
Neuropsychopharmacology reports · 2025
Omega-3 fatty acid supplementation for depression in children and adolescents.
The Cochrane database of systematic reviews · 2024
For
skin
Promising
Omega-3 fatty acid supplementation for depression in children and adolescents.
The Cochrane database of systematic reviews · 2024
Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials.
Prostaglandins, leukotrienes, and essential fatty acids · 2018
Therapeutic Benefits of Topical Omega-3 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review.
Journal of cosmetic dermatology · 2025

Typical dose range

Within evidence-supported amounts. Start at the low end and titrate up only if needed.

10002000 mg
with meal

What to expect

Effect timing depends on the goal — check the evidence cards above for goal-specific notes.